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Dag diacylglycerol

A diglyceride, or diacylglycerol (DAG), is a glyceride consisting of two fatty acid chains covalently bonded to a glycerol molecule through ester linkages. Two possible forms exist, 1,2-diacylglycerols and 1,3-diacylglycerols. DAGs can act as surfactants and are commonly used as emulsifiers in processed foods Diacylglycerol, Diacylglycerin, Abk.DAG, ein second messenger, der eine der wichtigsten Schaltstellen der Signaltransduktion ist. DAG kann auf zwei verschiedenen Wegen entstehen: Zum einen durch die Spaltung von Phosphatidylinositol-4,5-diphosphat, die durch die Phospholipase C katalysiert wird und damit an den Phosphoinositol-Signalweg gekoppelt ist

Diac y lglycer o l s, Diacylglycerin, Abk. DAG, sekundärer Bote, der im Zusammenhang mit dem Phosphatidylinositol-Metabolismus (sog. IP3-Weg) entsteht. DAG stellt eine wichtige Schaltstelle der Signaltransduktion dar, da hier mehrere Signalwege gebündelt werden und mehrere Signalwege von diesem Molekül abzweigen 1,2-Diacyl-sn-glycerine [auch einfach Diacylglycerine (DAG)] sind natürlich vorkommende chemische Verbindungen des Glycerins mit sn-Konfiguration, und zwar dessen Fettsäure - Ester mit den Fettsäuren Capronsäure, Ölsäure, Palmitinsäure, Arachidonsäure oder Stearinsäure

Diglyceride - Wikipedi

  1. Diacylglycerol (1,2-diacyl-sn -glycerol, DAG) has multiple roles in cellular metabolism. DAG has long been known as an important intermediate in the biosynthesis of glycerolipids in eukaryotic cells (1), and it has also been shown to be an important effector in the process of signal transduction across cellular membranes (2)
  2. Role of diacylglycerol (DAG) in hormonal induction of S phase in hepatocytes: the DAG-dependent protein kinase C pathway is not activated by epidermal growth factor (EGF), but is involved in mediating the enhancement of responsiveness to EGF by vasopressin, angiotensin II, and norepinephrin
  3. Diacylglycerol kinase (DGK or DAGK) is a family of enzymes that catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA), utilizing ATP as a source of the phosphate. In non-stimulated cells, DGK activity is low, allowing DAG to be used for glycerophospholipid biosynthesis, but on receptor activation of the phosphoinositide pathway, DGK activity increases, driving the.
  4. We developed a subcellular fractionation method to quantify diacylglycerol (DAG) stereoisomers and ceramides in the endoplasmic reticulum (ER), mitochondria, plasma membrane (PM), lipid droplets, and cytosol. Acute knockdown (KD) of diacylglycerol acyltransferase-2 in liver induced HIR in rats
  5. Synonym: IP3-Kaskade. 1 Definition. Die IP 3-Signaltransduktion ist ein Mechanismus, durch den Peptidhormone ihre intrazelluläre Wirkung entfalten. Zentraler Bestandteil dieses Signalweges ist der Botenstoff Inositoltriphosphat, kurz IP 3.. 2 Hintergrund. IP 3 (Inositol-1,4,5-trisphosphat) ist eine aus einem Phospholipid hervorgehende zyklische Verbindung, welche während des IP 3-Weges aus.

Diacylglycerol (DAG) und die Proteinkinase C Diacylglyceride sind Bestandteile von Glycerolipiden in der Zellmembran (z.B. als Vorstufe der Triglyceride). Bei der Spaltung des Phosphoinositids durch Phosphoinositidase (Phospholipase C) entstehen Phosphatidyl-inositol-4,5-diphosphat (PIP2) und Inositol-1,4,5-triphosphat (IP3) Diacylglycerol (DAG) is a neutral lipid involved in various metabolic pathways in the cell. It is an important component of membranes that also acts as a secondary messenger. It was shown that DAG is involved among others in multiple processes and pathways, e.g. protein transport, vesicle secretion, insulin signaling, cell growth, and proliferatio Diacylglycerol is found in small amounts in plant oils. In its concentrated form, it is used to replace fats in the diet. Diacylglycerol is used to promote weight loss and to treat high levels of..

The Diacylglycerol Kinase Inhibitor II, also referenced under CAS 120166-69-0, controls the biological activity of Diacylglycerol KInase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications Diacylglycerol (DAG) is a world leading anti-obesity functional cooking oil synthesized via structural modification of conventional fats and oils. DAG exits in three stereoisomers namely sn-1,2-DAG, sn-1,3-DAG, and sn-2,3-DAG.DAG particularly sn-1,3-DAG demonstrated to have the potential in suppressing body fat accumulation and lowering postprandial serum triacylglycerol, cholesterol and. Neben Diacylglycerol hat DAG andere Bedeutungen. Sie sind auf der linken Seite unten aufgeführt. Bitte scrollen Sie nach unten und klicken Sie, um jeden von ihnen zu sehen. Für alle Bedeutungen von DAG klicken Sie bitte auf Mehr. Wenn Sie unsere englische Version besuchen und Definitionen von Diacylglycerol in anderen Sprachen sehen möchten, klicken Sie bitte auf das Sprachmenü rechts.

Die cPKC- Isoformen werden durch die Sekundärsignale Ca 2+ und Diacylglycerin (DAG) aktiviert, die nPKC-Isoformen werden nur durch DAG aktiviert, und aPKC sind dagegen Ca 2+ - und DAG-unabhängig. Zusätzlich existieren weitere, zell- und isoformabhängige Aktivierungs- und Inaktivierungswege Clinical trials have focused on the use of diacylglycerol (DAG) oil as adjunctive therapy for weight loss and body fat reduction, especially in metabolic syndrome

In biochemical signaling, diacylglycerol (DAG) functions as a second messenger signaling lipid, a resultant of a reaction conducted by enzyme phospholipase C (PLC) (a membrane-bound enzyme) that, through the same reaction, produces inositol triphosphate (IP3). Although inositol triphosphate (IP 3) diffuses into the cytosol, diacylglycerol (DAG) stays close to the plasma membrane, due to its. DAG (Diacylglycerol) Assay Kit: Artikelnummer: MBS-MBS169284: Hersteller Artikelnummer: MBS169284: Hersteller: MyBiosource: Kategorie: Kits/Assays: Anzahl. 638,00 € Menge 100 assays in den Warenkorb * Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten Artikel vergleichen; PDF Datenblatt; Direkt bestellen. Tel: +49 (0)89 3799666-6 Kostenlos: 0800. DAG Assay Kit measures diacylglycerol content in samples by a coupled enzymatic reaction system. First, kinase is used to phosphorylate DAG samples, yielding phosphatidic acid. Next, a lipase is used to hydrolyze phosphatidic acid to glycerol-3-phosphate. Finally, the glycerol-3- phosphate product is oxidized by glycerol-3-phosphate oxidase (GPO), producing hydrogen peroxide which reacts with. Diacylglycerol Signaling . The second messenger diacylglycerol (DAG), which is generated by members of the phospholipase C superfamily, does not only bind to and activate protein kinase C enzymes but also regulates a variety of other, as yet not well characterized target proteins (Brose and Rosenmund, 2002; Brose et al., 2004). The aim of our research is the characterization of neuronal non. Diacylglycerol (DAG) is an important second messenger. Phorbol esters (PE) are analogues of DAG and potent tumour promoters that cause a variety of physiological changes when administered to both cells and tissues. DAG activates a family of serine/threonine protein kinases, collectively known as protein kinase C (PKC) . Phorbol esters can directly stimulate PKC. The N-terminal region of PKC.

Diacylglycerol - Kompaktlexikon der Biologi

IJMS | Free Full-Text | DAG/PKCδ and IP3/Ca2+/CaMK IIβBIOL2060: Signal Transduction Mechanisms:II Messengers and

Diacylglycerol - Lexikon der Biologi

  1. Diacylglycerol Bei Diacylglycerol handelt es sich um ein Produkt der Spaltung des Membranlipids Phosphatidylinositol-4,5-bisphosphat (PIP2) durc
  2. dict.cc | Übersetzungen für 'Diacylglycerol' im Englisch-Deutsch-Wörterbuch, mit echten Sprachaufnahmen, Illustrationen, Beugungsformen,.
  3. Diacylglycerol DAG Übersetzung, Englisch - Italienisch Wörterbuch, Siehe auch 'dialogue',dialling code',dial.',diary', biespiele, konjugatio
  4. Diacylglycerol (DAG) is a key secondary lipid messenger for transducing signals downstream of many receptors expressed by hematopoietic cells. DAG has shown to be important in driving the activation, proliferation, migration, and effector function of adaptive and innate immune cells
  5. Diacylglycerol (DAG) is a glyceride consisting of two fatty acid chains linked by a central glycerol backbone. It is a precursor to lipids such as triglycerides and phospholipids and functions as a second messenger signaling lipid
  6. e (PtdEtn) and PtdCho (Figure 1). Two mamma- lian enzymes, choline/ethanola
Trimethylamine oxide accumulation in marine animals

1,2-Diacylglycerine - Wikipedi

  1. g unit(s) DN do
  2. Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:2175712, PubMed:15544348). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed.
  3. Diacylglycerol kinases (DGKs) belong to a family of cytosolic kinases that regulate the phosphorylation of diacylglycerol (DAG), converting it into phosphatidic acid (PA). There are 10 known mammalian DGK isoforms, each with a different tissue distribution and substrate specificity
  4. Triacylglycerol (TAG) is known to be synthesized in a reaction that uses acyl-CoA as acyl donor and diacylglycerol (DAG) as acceptor, and which is catalyzed by the enzyme acyl-CoA:diacylglycerol acyltransferase. We have found that some plants and yeast also have an acyl-CoA-independent mechanism for TAG synthesis, which uses phospholipids as acyl donors and DAG as acceptor
Diacylglycerol Activation of Protein Kinase Cε and Hepatic

Nonalcoholic fatty liver disease is strongly associated with hepatic insulin resistance (HIR); however,the key lipid species and molecular mechanisms linking these conditions are widely debated. We developed a sub- cellular fractionation method to quantify diacylglycerol (DAG) stereoisomers and ceramides in the endo An acute phase occurring within several minutes and a sustained phase developing within more than 30 min of hypoxic ventilation [12-17]. TRPC6 belongs to the TRPC3/6/7 subfamily of TRP channels which can be activated by diacylglycerol (DAG), independently of protein kinase C [19,20] Diacylglycerol may also be referred to as Enova, DAG or DAG oil. DAG is commonly used to aid in weight loss. DAG is commonly used to aid in weight loss and to reduce body-fat levels. Diacylglycerol is immediately burned as energy when consumed, which makes this fatty acid a very popular alternative to conventional oils Крім Diacylglycerol, DAG має інші значення. Вони перераховані на лівій нижче. Будь ласка, прокрутіть униз і натисніть, щоб побачити кожен з них. Для всіх значень DAG, будь ласка, клацніть більше . Якщо ви відвідуєте нашу. Diacylglycerol acts as a precursor to many lipids (e.g. triglycerides, phospholipids); however, DAG also functions as a second messenger signalling lipid, produced through hydrolysis of PIP2 by phospholipase C, which initiates intracellular Ca2+ release and PKC activation. Ultimately, the PKC enzymes are involved with many modifications to.

Diacylglycerol. Cite. Download. Share. Tweet. Email. PubChem CID: 6026790: Structure: Find Similar Structures. Molecular Formula: C 37 H 70 O 5: Synonyms: Diacylglycerol. Diacylglycerols. SCHEMBL638396. Glycerol 1-palmitate 2-oleate. 45346-EP2289893A1. More... Molecular Weight: 594.9 g/mol. Dates: Modify . 2020-11-21. Create . 2005-09-13 . Contents. 1 Structures Expand this section. 2 Names. these domains likely bind DAG, no DGK C1 domain has been conclusively shown to bind diacylglycerol. The C1 domains of mammalian DGKs a, b, g, d, h, and y have been tested for their ability to bind PDBu, a long-lived DAG analog,butonlytheC1AdomainsofDGKsband g could successfully bind [Sakane et al., 1996b; Shindo et al., 2001, 2003]. And based o

Diacylglycerol - an overview ScienceDirect Topic

  1. ating DAG signaling and activating PA-mediated pathways
  2. Jetzt Anti-DGKI, NT (Diacylglycerol Kinase iota, DAG Kinase iota, Diglyceride Kinase iota, DGK-iota) (Azid, Artikelnummer: D3441-87-APC.200 von United States Biological bei Biomol kaufen
  3. Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed: 7809169)
  4. Both diacylglycerol (DAG) and phosphatidic acid (PA) are important membrane lipids and second messengers that contribute to cellular processes either by their biophysical effect on the membrane or by recruiting proteins to the membrane

Role of diacylglycerol (DAG) in hormonal induction of S

Synonym: Anti-CDP-DAG synthase 2, Anti-CDP-DG synthetase 2, Anti-CDP-diacylglycerol synthase 2, Anti-CDP-diglyceride pyrophosphorylase 2, Anti-CDP-diglyceride synthetase 2, Anti-CDS 2, Anti-CTP:phosphatidate cytidylyltransferase 2, Anti-Phosphatidate cytidylyltransferase In the PI-signal, diacylglycerol (DAG) is the first identified mammalian second messenger to enhance the activity of protein kinase C (PKC) and it is converted to phosphatidate, another messenger, by DAG kinase (DGK) 1,2-diacylglycerol (DAG) je ester glycerolu a určité (obvykle vyšší mastné kyseliny).Obvykle se tím myslí diglycerid na buněčné membráně vznikající odstraněním inositoltrifosfátu (IP 3) z fosfolipidové molekuly. Tato enzymatická reakce probíhá v těle činností fosfolipázy C.Z rozloženého fosfolipidu vznikne IP 3 a DAG, obě molekuly mohou sloužit jako druzí.

Um die Steuerung von TRPC6-Kanälen durch Diacylglycerol (DAG) während der HPV zu untersuchen, wurde in der vorliegenden Dissertation die Rolle des potenziellen TRPC6-Aktivators DAG an isolierten, perfundierten und ventilierten Mauslungen mittels pharmakologischer Beeinflussung des DAG-Stoffwechsels durch R59949 (DAG-Kinase-Inhibitor), 1-Oleoyl-2-acetyl-sn-glycerol (OAG) (DAG-Analogon) und U73122 (PLC-Inhibitor) überprüft Diacylglycerol (DAG), the product of the PLC-catalyzed PI(4,5)P 2 hydrolysis, activates protein kinase C (PKC). PKC is known to potentiate TRPV1 activity during activation of G protein-coupled receptors, but it is not known whether DAG modulates TRPV1 during desensitization. We found here that inhibition of diacylglycerol kinase (DAGK) enzymes reduces desensitization of native TRPV1 in. Introduction Diacylglycerol (DAG) is a lipid signal messenger which is an essential second messenger in mammalian cells. Is glycerol derivative that have two hydroxyl groups esterified by fatty acids. 6/21/2016by Yonas Teshome 4 R and R' are saturated or unsaturated hydrocarbon chains 5 Diacylglycerol (DAG) is a key signaling lipid and intermediate in lipid metabolism. Our knowledge of DAG distribution and dynamics in cell membranes is limited. Using live-cell fluorescence microscopy we investigated the localization of yeast cytosolic-facing pools of DAG in response to conditions where lipid homeostasis and DAG levels were known to be altered. Two main pools were monitored. Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed.

Diacylglycerol (DAG)-lactones, a New Class of Protein Kinase C (PKC) Agonists, Induce Apoptosis in LNCaP Prostate Cancer Cells by Selective Activation of PKCα. Journal of Biological Chemistry 2002 , 277 (1) , 645-655 Diacylglycerol kinases (DGKs) are members of a lipid kinase family. There are 10 known Mammalian DGK isoforms grouped based on their regulatory domains into 5 subtypes. DGKs contribute to the control of the immune system response through catalyzing the conversion of the second messenger lipid diacylglycerol (DAG) to phosphatidic acid (PA) Diacylglycerol is a minor component of various edible oils and fats. It is synthesized commercially by enzyme-catalyzed esterification of glycerol with fatty acids from oils such as canola, soybean, corn, and olive oil to produce an 80% mixture of 1,3-diglyceride and 1,2-diglyceride in a 7 to 3 ratio. Diacylglycerol is used orally for weight loss and hypertriglyceridemia dict.cc | Übersetzungen für 'Diacylglycerol DAG' im Norwegisch-Deutsch-Wörterbuch, mit echten Sprachaufnahmen, Illustrationen, Beugungsformen,.

IJMS | Free Full-Text | Transcriptional Regulation of Acyl

Diacylglycerol kinase - Wikipedi

Signaling at the Synapse - Phytecs

A Membrane-Bound Diacylglycerol Species Induces PKCϵ

IP3-Signaltransduktion - DocCheck Flexiko

Medicine: DAG. academic2.ru RU. EN; DE; FR; ES; Запомнить сай Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The DAG kinase domain is assumed to be an accessory domain. Upon cell stimulation, DAG kinase converts DAG into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. It catalyses the reaction: ATP + 1,2-diacylglycerol = ADP + 1,2-diacylglycerol 3. dict.cc | Übersetzungen für 'Diacylglycerol DAG' im Slowakisch-Deutsch-Wörterbuch, mit echten Sprachaufnahmen, Illustrationen, Beugungsformen,.

Digestion of lipids

Second Messenger - Chemgapedi

dict.cc | Übersetzungen für 'Diacylglycerol DAG' im Rumänisch-Deutsch-Wörterbuch, mit echten Sprachaufnahmen, Illustrationen, Beugungsformen,. Acylglycerid-Verteilung: Diacylglyceride (DAG) eur-lex.europa.eu. eur-lex.europa.eu. On 17 April 2002 Archer Daniels Midland Company (hereafter 'ADM') made a request to the competent authorities of the Netherlands to place diacylglycerol oil of plant origin on the market as a novel food for use in cooking oils, fat spreads, salad dressings, mayonnaise, drinks presented as a replacement for one. The ELISA Genie Diacylglycerol (DAG) ELISA Kits are designed for the competitive measurement of analytes in a wide variety of samples. As today's scientists demand high quality consistent data for high impact journals, ELISA Genie have developed a range of sensitive, fast and reliable ELISA kit assays to meet and exceed those demands. Our assay kits use a competitive ELISA technique and each.

Diacylglycerol-evoked activation of PKC and PKD isoforms

Dysregulated GPCR Signaling and Therapeutic Options in

Diacylglycerol: Uses, Side Effects, Interactions, Dosage

Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA), and both DAG and PA are lipid mediators in the cell. Here we show that DGK1 in rice (Oryza sativa) plays important roles in root growth and development DAG - Diacylglycerol. PCR Polymerase Chain Reaction; LH Luteinizing Hormone; MRI Magnetic Resonance Imaging; WT Wild-Type; ER Endoplasmic Reticulum; UV Ultraviolet; CPU Central Processing Unit; HIV Human Immunodeficiency Virus; WHO World Health Organization; CNS Central Nervous System; APTT Activated Partial Thromboplastin Time; MD Molecular Dynamics; CK Creatine Kinase; ALL Acute Lymphocytic. Diacylglycerol O-Acyltransferases (DGATs), EC 2.3.1.20, are enzymes that catalyze the final step of triglyceride (TG) synthesis, the covalent attachment of fatty acyl-CoA and diacylglycerol (DAG).There have been two DGAT isoforms identified to date, DGAT1 and DGAT2, which are members of the MBOAT and DAGAT families of acyltransferases, respectively Diacylglycerol ELISA Kits The ELISA (enzyme-linked immunosorbent assay) is a widely used application for detecting and quantifying proteins and antigens from various samples. Target-specific ELISA kits are available from a variety of manufacturers and can help streamline your immunodetection experiments Diacylglycerol (DAG) is one of the best-studied second messengers of eukaryotic cells 1.It is released by stimulus-induced activation of phospholipase C (PLC), which cleaves the minor plasma.

Duration of dual antiplatelet therapy in acute coronary

diacylglycerol Sigma-Aldric

Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA), and both DAG and PA are lipid mediators in the cell. Here we show that DGK1 in rice (Oryza sativa) plays important roles in root growth and development. Two independent OsDGK1-knockout (dgk1) lines exhibited a higher density of lateral roots (LRs) and thinner seminal roots (SRs), whereas OsDGK1. The production of DAG in the membrane facilitates translocation of PKC from the cytosol to the plasma membrane. (See References) Diacylglycerol mimicks the effects of the tumor-promoting compounds phorbol esters. Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Diacylglycerol (DAG) submarket forecasts from 2020-2027 covering submarket 1, submarket 2 submarket 3; Various industry models such as SWOT analysis, Pestle Analysis, Porter's Five Force model, Value Chain Analysis pertaining to diacylglycerol (dag) market; Analysis of the key factors driving and restraining the growth of the global, regional and country level diacylglycerol (dag) markets from. Phospholipase C produces two second messengers - diacylglycerol (DAG), which remains in the membrane, and inositol triphosphate (IP3), which triggers the release of calcium ions (Ca2+) from intracellular stores. Genetically encoded sensors based on a single circularly permuted fluorescent protein (FP) are robust tools for studying intracellular Ca2+ dynamics

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Seven-transmembrane receptor (7TMR) signaling is transduced by second messengers such as diacylglycerol (DAG) generated in response to the heterotrimeric guanine nucleotide-binding protein Gq and is terminated by receptor desensitization and degradation of the second messengers. We show that β-arrestins coordinate both processes for the Gq-coupled M1 muscarinic receptor. β-Arrestins. Editorial: Tweaking T cell receptor signaling thresholds through DAG: the role of diacylglycerol kinase ζ in T cell responses to TGF‐β . Craig M. Walsh. Corresponding Author. E-mail address: cwalsh@uci.edu. Institute for Immunology and Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA. Institute for Immunology and Dept. of Molecular Biology.

The diacylglycerol kinases (DGKs) are master regulator kinases that control the switch from diacylglycerol (DAG) to phosphatidic acid (PA), two lipids with important structural and signaling properties. Mammalian DGKs distribute into five subfamilies that regulate local availability of DAG and PA pools in a tissue- and subcellular-restricted manner. Pharmacological manipulation of DGK activity. Diacylglycerol kinases (DGKs) are a family of enzymes that regulate the relative levels of diacylglycerol (DAG) and phosphatidic acid (PA) in cells by phosphorylating DAG to produce PA. Both DAG. The diacylglycerol kinases (DGKs) are master regulator kinases that control the switch from diacylglycerol (DAG) to phosphatidic acid (PA), two lipids with important structural and signaling. However, their precise activation mechanism has remained largely elusive for a long time, as the TRPC4 and TRPC5 channels were considered as being insensitive to the second messenger diacylglycerol (DAG) in contrast to the other TRPC channels. Recent findings indicate that the C-terminal interactions with the scaffolding proteins Na+/H+ exchanger regulatory factor 1 and 2 (NHERF1 and NHERF2. Diacylglycerol kinases (DGKs) catalyze the conversion of the lipid signaling molecule DAG into phosphatidic acid (PA), both of which have distinct effects. Merino-Cortés et al . found that the DGKζ isoform was critical in promoting signaling required for the optimal function of B cells. Compared with wild-type B cells, DGKζ-deficient B cells exhibited decreased mechanical forces at the.

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